Magdalena Zernicka-Goetz Group

Mammalian Embryo and Stem Cell Group

The chromatin modifier Satb1 regulates cell fate through Fgf signalling in the early mouse embryo.

Goolam M, Zernicka-Goetz M.

Development. 2017 Apr 15;144(8):1450-1461. doi: 10.1242/dev.144139. Epub 2017 Mar 13.

 

 

Assembly of embryonic and extraembryonic stem cells to mimic embryogenesis in vitro.

Harrison SE, Sozen B, Christodoulou N, Kyprianou C, Zernicka-Goetz M.

Science. 2017 Apr 14;356(6334). pii: eaal1810. doi: 10.1126/science.aal1810. Epub 2017 Mar 2.

 

 

Self-organization of the human embryo in the absence of maternal tissues.

Shahbazi MN, Jedrusik A, Vuoristo S, Recher G, Hupalowska A, Bolton V, Fogarty NM, Campbell A, Devito LG, Ilic D, Khalaf Y, Niakan KK, Fishel S, Zernicka-Goetz M.

Nat Cell Biol. 2016 Jun;18(6):700-8. doi: 10.1038/ncb3347. Epub 2016 May 4.

 

 

Self-organization of the in vitro attached human embryo.

Deglincerti A, Croft GF, Pietila LN, Zernicka-Goetz M, Siggia ED, Brivanlou AH.

Nature. 2016 May 4;533(7602):251-4. doi: 10.1038/nature17948.

 

 

Mouse model of chromosome mosaicism reveals lineage-specific depletion of aneuploid cells and normal developmental potential.

Bolton H, Graham SJ, Van der Aa N, Kumar P, Theunis K, Fernandez Gallardo E, Voet T, Zernicka-Goetz M.

Nat Commun. 2016 Mar 29;7:11165. doi: 10.1038/ncomms11165.

 

 

Heterogeneity in Oct4 and Sox2 Targets Biases Cell Fate in 4-Cell Mouse Embryos.

Goolam M, Scialdone A, Graham SJ, Macaulay IC, Jedrusik A, Hupalowska A, Voet T, Marioni JC, Zernicka-Goetz M.

Cell. 2016 Mar 24;165(1):61-74. doi: 10.1016/j.cell.2016.01.047.

 

 

The Acquisition of Cell Fate in Mouse Development: How Do Cells First Become Heterogeneous?

Graham SJ, Zernicka-Goetz M.

Curr Top Dev Biol. 2016;117:671-95. doi: 10.1016/bs.ctdb.2015.11.021. Epub 2016 Jan 21.

 

 

The BAF chromatin remodelling complex is an epigenetic regulator of lineage specification in the early mouse embryo.

Panamarova M, Cox A, Wicher KB, Butler R, Bulgakova N, Jeon S, Rosen B, Seong RH, Skarnes W, Crabtree G, Zernicka-Goetz M.

Development. 2016 Apr 15;143(8):1271-83. doi: 10.1242/dev.131961. Epub 2016 Mar 7.

 

 

Over-expression of Plk4 induces centrosome amplification, loss of primary cilia and associated tissue hyperplasia in the mouse.

Coelho PA, Bury L, Shahbazi MN, Liakath-Ali K, Tate PH, Wormald S, Hindley CJ, Huch M, Archer J, Skarnes WC, Zernicka-Goetz M, Glover DM.

Open Biol. 2015 Dec;5(12):150209. doi: 10.1098/rsob.150209.

 

 

Polarity and cell division orientation in the cleavage embryo: from worm to human.

Ajduk A, Zernicka-Goetz M.

Mol Hum Reprod. 2015 Dec 9. pii: gav068. [Epub ahead of print]

 

 

Mapping the journey from totipotency to lineage specification in the mouse embryo.

Leung CY, Zernicka-Goetz M.

Curr Opin Genet Dev. 2015 Oct;34:71-6. doi: 10.1016/j.gde.2015.08.002. Epub 2015 Sep 3. Review.

 

 

Development of the anterior-posterior axis is a self-organizing process in the absence of maternal cues in the mouse embryo.

Bedzhov I, Bialecka M, Zielinska A, Kosalka J, Antonica F, Thompson AJ, Franze K, Zernicka-Goetz M.

Cell Res. 2015 Dec;25(12):1368-71. doi: 10.1038/cr.2015.104. Epub 2015 Sep 4.

 

 

G&T-seq: parallel sequencing of single-cell genomes and transcriptomes.

Macaulay IC, Haerty W, Kumar P, Li YI, Hu TX, Teng MJ, Goolam M, Saurat N, Coupland P, Shirley LM, Smith M, Van der Aa N, Banerjee R, Ellis PD, Quail MA, Swerdlow HP, Zernicka-Goetz M, Livesey FJ, Ponting CP, Voet T.

Nat Methods. 2015 Jun;12(6):519-22. doi: 10.1038/nmeth.3370. Epub 2015 Apr 27.

 

Cell death and morphogenesis during early mouse development: are they interconnected?

Bedzhov I, Zernicka-Goetz M.

Bioessays. 2015 Apr;37(4):372-8. doi: 10.1002/bies.201400147. Epub 2015 Jan 15.

 

 

Jedrusik A, Cox A, Wicher K, Glover D, Zernicka-Goetz M.

Maternal-zygotic knockout reveals a critical role of Cdx2 in the morula to blastocyst transition.

Dev Biol. 2014 Dec 12. pii: S0012-1606(14)00630-7. doi: 10.1016/j.ydbio.2014.12.004. [Epub ahead of print]

 

 

Graham SJ, Wicher KB, Jedrusik A, Guo G, Herath W, Robson P, Zernicka-Goetz M.

BMP signalling regulates the pre-implantation development of extra-embryonic cell lineages in the mouse embryo.

Nat Commun. 2014 Dec 16;5:5667. doi: 10.1038/ncomms6667.

 

 

Bedzhov I, Leung CY, Bialecka M, Zernicka-Goetz M.

In vitro culture of mouse blastocysts beyond the implantation stages.

Nat Protoc. 2014 Dec;9(12):2732-9. doi: 10.1038/nprot.2014.186. Epub 2014 Oct 30.

 

 

Ajduk A, Biswas Shivhare S, Zernicka-Goetz M.

The basal position of nuclei is one pre-requisite for asymmetric cell divisions in the early mouse embryo.

Dev Biol. 2014 Aug 15;392(2):133-40. doi: 10.1016/j.ydbio.2014.05.009. Epub 2014 May 20.

 

 

Bedzhov I, Zernicka-Goetz M

Self-organizing properties of mouse pluripotent cells initiate morphogenesis upon implantation.

Cell. 2014 Feb 27;156(5):1032-44. doi: 10.1016/j.cell.2014.01.023. Epub 2014 Feb 13.

 

 

Christophorou MA, Castelo-Branco G, Halley-Stott RP, Oliveira CS, Loos R, Radzisheuskaya A, Mowen KA, Bertone P, Silva JC, Zernicka-Goetz M, Nielsen ML, Gurdon JB, Kouzarides T

Citrullination regulates pluripotency and histone H1 binding to chromatin.

Nature. 2014 Mar 6;507(7490):104-8. doi: 10.1038/nature12942. Epub 2014 Jan 26.

 

 

Coelho PA, Bury L, Sharif B, Riparbelli MG, Fu J, Callaini G, Glover DM, Zernicka-Goetz M

Spindle formation in the mouse embryo requires Plk4 in the absence of centrioles.

Dev Cell. 2013 Dec 9;27(5):586-97. doi: 10.1016/j.devcel.2013.09.029. Epub 2013 Nov 21.

 

 

Morris SA, Graham SJL, Jedrusik A, Zernicka-Goetz M

The differential response to Fgf signalling in cells internalized at different times influences lineage segregation in preimplantation mouse embryos.

Open Biol. 2013 Nov 20; 3, 130104

 

 

Duan EK, Wang H, Zernicka-Goetz M

Introduction to the special issue "Molecular Players in Early Pregnancy".

Mol Aspects Med. 2013 Oct;34(5):vi-vii. doi: 10.1016/S0098-2997(13)00054-X

 

 

Leunc CY, Zernicka-Goetz M

Angiomotin prevents pluripotent lineage differentiation in mouse embryos via Hippo pathway-dependent and -independent mechanisms.

Nat Commun. 2013;4:2251. doi: 10.1038/ncomms3251.

 

 

Skamagki M, Wicher KB, Jedrusik A, Ganguly S, Zernicka-Goetz M

Asymmetric Localization of Cdx2 mRNA during the First Cell-Fate Decision in Early Mouse Development.

Cell Rep. 2013 Feb 21; 3(2)

 

 

Morris SA, Guo Y, Zernicka-Goetz M.

Developmental plasticity is bound by pluripotency and the fgf and wnt signaling pathways.

Cell Rep. 2012 Oct 25;2(4):756-65

 

 

Morris SA, Zernicka-Goetz M.

Formation of distinct cell types in the mouse blastocyst.

Results Probl Cell Differ. 2012;55:203-17

 

 

Ajduk A, Zernicka-Goetz M.

Advances in embryo selection methods.

F1000 Biol Rep.. 2012;4:11

 

 

Morris SA, Grewal S, Barrios F, Patankar SN, Strauss B, Buttery L, Alexander M, Shakesheff KM, Zernicka-Goetz M.

Dynamics of anterior-posterior axis formation in the developing mouse embryo.

Nat Commun. 2012 Feb 14;3:673.

 

 

Ajduk A, Ilozue T, Windsor S, Yu Y, Seres KB, Bomphrey RJ, Tom BD, Swann K, Thomas A, Graham C, Zernicka-Goetz M.

Rhythmic actomyosin-driven contractions induced by sperm entry predict mammalian embryo viability.

Nat Commun. 2011 Aug 9;2:417.

 

 

Zernicka-Goetz M.

Proclaiming fate in the early mouse embryo.

Nat Cell Biol. 2011 Feb;13(2):112-4.

 

 

Sharif B, Na J, Lykke-Hartmann K, McLaughlin SH, Laue E, Glover DM, Zernicka-Goetz M.

The chromosome passenger complex is required for fidelity of chromosome transmission and cytokinesis in meiosis of mouse oocytes.

J Cell Sci. 2010 Dec 15;123(Pt 24):4292-300.

 

 

Zernicka-Goetz M, Huang S.

Stochasticity versus determinism in development: a false dichotomy?

Nat Rev Genet. 2010 Nov;11(11):743-4.

 

 

Parfitt DE, Zernicka-Goetz M.

Epigenetic modification affecting expression of cell polarity and cell fate genes to regulate lineage specification in the early mouse embryo.

Mol Biol Cell. 2010 Aug 1;21(15):2649-60.

 

 

Jedrusik A, Bruce AW, Tan MH, Leong DE, Skamagki M, Yao M, Zernicka-Goetz M.

Maternally and zygotically provided Cdx2 have novel and critical roles for early development of the mouse embryo.

Dev Biol. 2010 Apr 27.

 

 

Morris SA, Teo RT, Li H, Robson P, Glover DM, Zernicka-Goetz M.

Origin and formation of the first two distinct cell types of the inner cell mass in the mouse embryo.

Proc Natl Acad Sci U S A. 2010 Mar 22.

 

 

Wu Q, Bruce AW, Jedrusik A, Ellis PD, Andrews RM, Langford CF, Glover DM, Zernicka-Goetz M.

CARM1 is required in embryonic stem cells to maintain pluripotency and resist differentiation.

Stem Cells. 2009 Nov;27(11):2637-45.

 

 

Zernicka-Goetz M, Morris SA, Bruce AW.

Making a firm decision: multifaceted regulation of cell fate in the early mouse embryo.

Nat Rev Genet. 2009 Jul;10(7):467-77.

 

 

Meilhac SM, Adams RJ, Morris SA, Danckaert A, Le Garrec JF, Zernicka-Goetz M.

Active cell movements coupled to positional induction are involved in lineage segregation in the mouse blastocyst.

Dev Biol. 2009 Jul 15;331(2):210-21. Epub 2009 May 5.

 

 

Jedrusik A, Parfitt DE, Guo G, Skamagki M, Grabarek JB, Johnson MH, Robson P, Zernicka-Goetz M.

Role of Cdx2 and cell polarity in cell allocation and specification of trophectoderm and inner cell mass in the mouse embryo.

Genes Dev. 2008 Oct 1;22(19):2692-706.

 

 

Lykke-Andersen K, Gilchrist MJ, Grabarek JB, Das P, Miska E, Zernicka-Goetz M.

Maternal Argonaute 2 is essential for early mouse development at the maternal-zygotic transition.

Mol Biol Cell. 2008 Oct;19(10):4383-92.

 

 

Soares ML, Torres-Padilla ME, Zernicka-Goetz M.

Bone morphogenetic protein 4 signaling regulates development of the anterior visceral endoderm in the mouse embryo.

Dev Growth Differ. 2008 Sep;50(7):615-21.

 

 

Bischoff M, Parfitt DE, Zernicka-Goetz M.

Formation of the embryonic-abembryonic axis of the mouse blastocyst: relationships between orientation of early cleavage divisions and pattern of symmetric/asymmetric divisions.

Development. 2008 Mar;135(5):953-62.

 

 

Perea-Gomez A, Meilhac SM, Piotrowska-Nitsche K, Gray D, Collignon J, Zernicka-Goetz M.

Regionalization of the mouse visceral endoderm as the blastocyst transforms into the egg cylinder.

BMC Dev Biol. 2007 Aug 16;7:96.

 

 

Torres-Padilla ME, Richardson L, Kolasinska P, Meilhac SM, Luetke-Eversloh MV, Zernicka-Goetz M.

The anterior visceral endoderm of the mouse embryo is established from both preimplantation precursor cells and by de novo gene expression after implantation.

Dev Biol. 2007 Sep 1;309(1):97-112.

 

 

Frankenberg S, Smith L, Greenfield A, Zernicka-Goetz M.

Novel gene expression patterns along the proximo-distal axis of the mouse embryo before gastrulation.

BMC Dev Biol. 2007 Feb 15;7:8.

 

 

Torres-Padilla ME, Parfitt DE, Kouzarides T, Zernicka-Goetz M.

Histone arginine methylation regulates pluripotency in the early mouse embryo.

Nature. 2007 Jan 11;445(7124):214-8.

 

 

Na J, Lykke-Andersen K, Torres Padilla ME, Zernicka-Goetz M.

Dishevelled proteins regulate cell adhesion in mouse blastocyst and serve to monitor changes in Wnt signaling.

Dev Biol. 2007 Feb 1;302(1):40-9.

 

 

Torres-Padilla ME, Zernicka-Goetz M.

Role of TIF1alpha as a modulator of embryonic transcription in the mouse zygote.

J Cell Biol. 2006 Jul 31;174(3):329-38.

 

 

Zernicka-Goetz M.

The first cell-fate decisions in the mouse embryo: destiny is a matter of both chance and choice.

Curr Opin Genet Dev. 2006 Aug;16(4):406-12.

 

 

Na J, Zernicka-Goetz M.

Asymmetric positioning and organization of the meiotic spindle of mouse oocytes requires CDC42 function.

Curr Biol. 2006 Jun 20;16(12):1249-54.

 

 

Torres-Padilla ME, Bannister AJ, Hurd PJ, Kouzarides T, Zernicka-Goetz M.

Dynamic distribution of the replacement histone variant H3.3 in the mouse oocyte and preimplantation embryos.

Int J Dev Biol. 2006;50(5):455-61.

 

 

Richardson L, Torres-Padilla ME, Zernicka-Goetz M.

Regionalised signalling within the extraembryonic ectoderm regulates anterior visceral endoderm positioning in the mouse embryo.

Mech Dev. 2006 Apr;123(4):288-96.

 

 

Soares ML, Haraguchi S, Torres-Padilla ME, Kalmar T, Carpenter L, Bell G, Morrison A, Ring CJ, Clarke NJ, Glover DM, Zernicka-Goetz M.

Functional studies of signaling pathways in peri-implantation development of the mouse embryo by RNAi.

BMC Dev Biol. 2005 5:28.

 

 

Zernicka-Goetz M.

Developmental cell biology: cleavage pattern and emerging asymmetry of the mouse embryo.

Nat Rev Mol Cell Biol. 2005 6:919-28.

 

 

Moore CA, Zernicka-Goetz M.

PAR-1 and the microtubule-associated proteins CLASP2 and dynactin-p50 have specific localisation on mouse meiotic and first mitotic spindles.

Reproduction. 2005 130:311-20.

 

 

Piotrowska-Nitsche K, Zernicka-Goetz M

Spatial arrangement of individual 4-cell stage blastomeres and the order in which they are generated correlate with blastocyst pattern in the mouse embryo.

Mech Dev. 2005 122:487-500.

 

 

Plusa B, Hadjantonakis AK, Gray D, Piotrowska-Nitsche K, Jedrusik A, Papaioannou VE, Glover DM, Zernicka-Goetz M.

The first cleavage of the mouse zygote predicts the blastocyst axis.

Nature. 2005 434:391-5.

 

 

Plusa B, Frankenberg S, Chalmers A, Hadjantonakis AK, Moore CA, Papalopulu N, Papaioannou VE, Glover DM, Zernicka-Goetz M.

Downregulation of Par3 and aPKC function directs cells towards the ICM in the preimplantation mouse embryo.

J Cell Sci. 2005 118:505-15.

 

 

Piotrowska-Nitsche K, Perea-Gomez A, Haraguchi S, Zernicka-Goetz M.

Four-cell stage mouse blastomeres have different developmental properties.

Development. 2005 Feb;132(3):479-91.

 

 

Carpenter L, Zernicka-Goetz M.

Directing pluripotent cell differentiation using "diced RNA" in transient transfection.

Genesis. 2004 Nov;40(3):157-63.

 

 

Zernicka-Goetz M.

First cell fate decisions and spatial patterning in the early mouse embryo.

Semin Cell Dev Biol. 2004 5: 563-72.

 

 

Mesnard D, Filipe M, Belo JA, Zernicka-Goetz M.

The anterior-posterior axis emerges respecting the morphology of the mouse embryo that changes and aligns with the uterus before gastrulation.

Current Biol. 2004 14:184-96.

 

 

Gray, D., Plusa, B., Piotrowska, K., Glover, D. M., Tom, B. and Zernicka-Goetz, M.

First cleavage of the mouse embryo responds to egg geometry that reflects the position of sperm entry.

Current Biol. 2004 9:397-405.

 

 

Wang, Q.T., Piotrowska, K., Ciemerych, M.A., Milenkovic, L., Scott, M.P., Davis, R.W. and Zernicka-Goetz, M.

A genome-wide study of gene activity reveals developmental signaling pathways in the preimplantation mouse embryo.

Developmental Cell 2004 Jan: 6, 133-144.

 

 

Grabarek JB, Zernicka-Goetz M.

RNA interference in mammalian systems--a practical approach.

Adv Exp Med Biol. 2003;544:205-16.

 

 

Plusa B., Grabarek J.B., Piotrowska K., Glover D.M, Zernicka-Goetz M.

Site of the previous meiotic division defines cleavage orientation in the mouse embryo.

Nat Cell Biol. 2002 4:811-5.

 

 

Grabarek JB, Wianny F, Plusa B, Zernicka-Goetz M, Glover DM.

RNA interference by production of short hairpin dsRNA in ES cells, their differentiated derivatives, and in somatic cell lines.

Biotechniques. 2003 34:734-6, 739-44.

 

 

Zernicka-Goetz M.

Determining the first cleavage of the mouse zygote.

Reprod Biomed Online. 2003 6: 160-163.

 

 

Durcova-Hills G, Wianny F, Merriman J, Zernicka-Goetz M, McLaren A.

Developmental fate of embryonic germ cells (EGCs), in vivo and in vitro.

Differentiation. 2003 71:135-41.

 

 

Piotrowska K, Zernicka-Goetz M.

Early patterning of the mouse embryo - contributions of sperm and egg.

Development. 2002. 129:5803-13.

 

 

Grabarek JB, Plusa B, Glover DM, Zernicka-Goetz M.

Efficient delivery of dsRNA into zona-enclosed mouse oocytes and preimplantation embryos by electroporation.

Genesis, 2002. 32:269-76.

 

 

Plusa B, Piotrowska K, Zernicka-Goetz M.

Sperm entry position provides a surface marker for the first cleavage plane of the mouse zygote. Genesis, 2002. 32:193-8.

 

 

Zernicka-Goetz M.

Patterning of the embryo: the first spatial decisions in the life of a mouse.

Development, 2000. 129:815-29.

 

 

Piotrowska K, Wianny F, Pedersen RA, Zernicka-Goetz M.

Blastomeres arising from the first cleavage division have distinguishable fates in normal mouse development.

Development, 2001. 128:3739-40.

 

 

Zernicka-Goetz M, Pines J.

Use of Green Fluorescent Protein in mouse embryos.

Methods 2000. 24:55-60.

 

 

Piotrowska, K. and Zernicka-Goetz, M.

Role for sperm in spatial patterning of the early mouse embryo.

Nature 2001. 409:517-521.

 

 

Wianny, F and Zernicka-Goetz, M.

Specific interference with gene function by double stranded RNA in mouse. Nature Cell Biology, 2000. 2:70-75.

 

Ciemerych MA, Mesnard D, Zernicka-Goetz M.

Animal and vegetal poles of the mouse egg predict the polarity of the embryonic axis, yet are nonessential for development.

Development, 2000. 16:3467-74.

 

 

Zernicka-Goetz M.

Jumping the gun on mouse gene expression.

Nature, 2000. 6788:733.

 

 

Grabarek J, Zernicka-Goetz M.

Progression of mouse oocytes from metaphase I to metaphase II is inhibited by fusion with G2 cells. Zygote 2000. 8:145-51.

 

 

Zernicka-Goetz M, Pines J.

Cell lineage analysis. Applications of green fluorescent protein.

Methods Mol Biol, 2000. 135:279-87.

 

 

Weber, R., Wianny, F., Evans, M.J., Pedersen, R., and Zernicka-Goetz, M.

Polarity of the mouse embryo is anticipated before implantation.

Development, 1999. 126:5591-5598.

 

 

Wianny F, Tavares A, Evans MJ, Glover DM, Zernicka-Goetz M.

Mouse polo-like kinase 1 associates with the acentriolar spindle poles, meiotic chromosomes and spindle midzone during oocyte maturation.

Chromosoma, 1998. 6-7:430-9.

 

 

Zernicka-Goetz M.

Fertile offspring derived from mammalian eggs lacking either animal or vegetal poles.

Development, 1998. 23:4803-8.

 

 

Zernicka-Goetz M, Pines J, McLean Hunter S, Dixon JP, Siemering KR, Haseloff J, Evans MJ.

Following cell fate in the living mouse embryo.

Development, 1997. 6:1133-7.

 

 

Zernicka-Goetz M, Verlhac MH, Geraud G, Kubiak JZ.

Protein phosphatases control MAP kinase activation and microtubule organization during rat oocyte maturation.

Eur J Cell Biol. 1997. 1:30-8.

 

 

Zernicka-Goetz M, Pines J, Ryan K, Siemering KR, Haseloff J, Evans MJ, Gurdon JB.

An indelible lineage marker for Xenopus using a mutated green fluorescent protein.

Development. 1996. 2:3719-24.

 

 

Zernicka-Goetz M, Ciemerych MA, Kubiak JZ, Tarkowski AK, Maro B.

Cytostatic factor inactivation is induced by a calcium-dependent mechanism present until the second cell cycle in fertilized but not in parthenogenetically activated mouse eggs.

J Cell Sci. 1995. Pt 2:469-74.

 

 

Zernicka-Goetz M.

Activation of embryonic genes during preimplantation rat development.

Mol Reprod Dev, 1994. 1:30-5.

 

Zernicka-Goetz M, Maro B.

Okadaic acid affects spindle organization in metaphase II-arrested rat oocytes.

Exp Cell Res, 1993. 1:189-93.

 

 

Zernicka-Goetz M, Weber M, Maro B.

Full activation of the rat oocyte by protein synthesis inhibition requires protein phosphatase activity. Int J Dev Biol. 1993. 2:273-7.

 

 

Zernicka-Goetz M, Kubiak JZ, Antony C, Maro B.

Cytoskeletal organization of rat oocytes during metaphase II arrest and following abortive activation: a study by confocal laser scanning microscopy.

Mol Reprod Dev, 1993. 2:165-75.

 

 

Zernicka-Goetz M.

Spontaneous and induced activation of rat oocytes.

Mol Reprod Dev. 1991. 2:169-76.

 

 

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