Magdalena Zernicka-Goetz Group
Physiology, Development and Neuroscience
Mammalian Embryo and Stem Cell Group
Early embryos kept in check or how embryos coordinate the exit from pluripotency?
Pluripotent state transitions coordinate morphogenesis in mouse and human embryos. Shahbazi M et al., 2017 Nature
Pluripotency regulates mouse and human embryonic morphogenesis: cells in an unrestricted naive pluripotent state (Nanog+, yellow) fail to undergo proper morphogenesis and do not form the amniotic cavity (left). Loss of naive pluripotency (cells lacking Nanog expression) directs morphogenesis and amniotic cavity formation (right)..
The next generation of artificial embryos: Embryo-like structures built from stem cells capable of ‘gastrulation’, a key life event
Self-assembly of embryonic and two extra-embryonic stem cell types into gastrulating embryo-like structures. Sozen B et al., 2018. Nature Cell Biology
The remarkable ability of three stem cell types to self-assemble in vitro into gastrulating embryo-like structures (middle) undertaking spatio-temporal events of the gastrulating mammalian embryo (right).
How are experimental models shaping our understanding of early mammalian developement?
Deconstructing and reconstructing the mouse and human early embryo. Shahbazi, M and Zernicka-Goetz, M. 2018. Nature Cell Biology
A timely review on the post-implantation mammalian embryo and how recent technologies have helped to investigate form and function during development. We explore the complex processes of embryogenesis and the multiple regulatory levels involved.
In The Press:
A Perspective Series Investigating The Future of Fertility
An original series on the Future of Fertility by OZY looks at where science is headed — and who’s leading the charge.
Celebrating women in science: a new profile of the work in our lab examines our attempts to solve the mysteries of the embryo. Written by science journalist, Marissa Fessenden. Click here to view the story.
Illustration by Zoe Van Dijk.
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Meet the lab
Prof. Magdalena
Zernicka-Goetz
Dr. Andy Cox
Postdoctoral Scientist
Lab Manager
Dr. Marta Shahbazi
Post-doctoral Scientist
Dr. Neophytos Christodoulou
Postdoctoral Scientist
Dr. Gianluca Amadei
Postdoctoral Scientist
Dr. Matteo Mole
Postdoctoral Scientist
Berna Sozen
Postdoctoral Scientist
Meng Zhu
PhD Student
Christos Kyprianou
PhD Student
Shruti Singla
PhD Student
Lorenzo Carlo Orietti
PhD Student
Antonia Weberling
PhD Student
Charlotte Handford
PhD Student
Kirsty Mackinlay
PhD Student
Hannah Sharplin Lab Technician/PA
Oscars
Best idea:
Christos
Best results:
Meng
Our Research
The long-term goal of our work is to understand the development of cell lineages and patterning in the early mammalian embryo.
