Magdalena Zernicka-Goetz Group

Mammalian Embryo and Stem Cell Group

Early embryos kept in check or how embryos coordinate the exit from pluripotency?

Marta Shahbazi

Pluripotency regulates mouse and human embryonic morphogenesis: cells in an unrestricted naive pluripotent state (Nanog+, yellow) fail to undergo proper morphogenesis and do not form the amniotic cavity (left). Loss of naive pluripotency (cells lacking Nanog expression) directs morphogenesis and amniotic cavity formation (right)..

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